BioRender Template

DDR1 signaling pathway

Created by

Xiang Fei

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Description:

This template shows how collagen binding to the DDR1 receptor triggers tyrosine phosphorylation and activates five downstream branches: NF-kB/p62/NRF2 driving tumor growth, PI3K/AKT/mTOR driving metastasis, PYK2/ERK1/2/cMYC driving drug resistance, LATS1/2/YAP/TEAD driving fibrosis, and collagen alignment suppressing tumor immunity. DDR1 inhibitors are shown blocking the receptor's kinase domain.

Updated

August 2026

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