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Derivation of microglia from human stem cells aligns with developmental ontogeny
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Description
Derivation of microglia from human stem cells according to the Guttikonda et al protocol (Nature Neuroscience 2021) recapitulates development of tissue-resident microglia. Microglia are derived from yolk sac progenitors early in development, in contrast to monocyte-derived macrophages which derive from bone marrow hematopoiesis.
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