Detecting Viral Invaders
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This template shows viral RNA sensors RIG-I and MDA5 converging on MAVS at the mitochondria, branching into TRAF2/FADD and TRAF6/TAK1 signaling that activates IRF3, IRF7, NF-kB, and JNK pathways. These transcription factors bind PRD elements in the IFN-beta promoter to drive interferon gene expression.
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This template shows viral RNA sensors RIG-I and MDA5 converging on MAVS at the mitochondria, branching into TRAF2/FADD and TRAF6/TAK1 signaling that activates IRF3, IRF7, NF-kB, and JNK pathways. These transcription factors bind PRD elements in the IFN-beta promoter to drive interferon gene expression.








