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BioRender Template
Direct DNA Damage
Creator
s
Description
Direct DNA damage is highly dependent on the linear energy transfer (LET) of the radiation. High-LET radiation (e.g., alpha particles, neutrons) deposits energy densely along its path, resulting in clustered DNA damage that is difficult for cellular repair machinery to resolve. In contrast, low-LET radiation (e.g., X-rays, gamma rays) typically induces more dispersed lesions, which are more amenable to repair through non-homologous end joining (NHEJ) or homologous recombination (HR).
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