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DNA Methylation Levels During Mammalian Development

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Lisa Vrooman

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BioRender Team

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Description: This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. During prenatal development, highly methylated primordial germ cells (PGCs) undergo methylation before gametes are re-methylated in a sex-specific manner. Following fertilization, methylation of the inherited oocyte and sperm genomes are differentially erased during preimplantation embryo development. Imprinted genes and intracisternal A-type particles, however, remain highly methylated. New methylation is established associated with cell differentiation.

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What does the DNA Methylation Levels During Mammalian Development template show?

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. During prenatal development, highly methylated primordial germ cells (PGCs) undergo methylation before gametes are re-methylated in a sex-specific manner. Following fertilization, methylation of the inherited oocyte and sperm genomes are differentially erased during preimplantation embryo development. Imprinted genes and intracisternal A-type particles, however, remain highly methylated. New methylation is established associated with cell differentiation.

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