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DNA Repair Mechanisms
Description
This template shows five DNA repair pathways matched to their damage type, base excision repair for single-strand breaks, nucleotide excision repair for bulky lesions and crosslinks, mismatch repair for base mismatches, and homologous recombination or non-homologous end joining for double-strand breaks. Key proteins in each pathway are listed, with several marked as cancer biomarkers including PARP1/2, ERCC1/XPF, MSH2/MSH6, BRCA2/FANCD, and DNA PKs.
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