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DNA topology in chromatin regulation across different scales

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Shuai Li

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Description: DNA topology interacts with chromatin factors and processes on a spectrum of scales from small to large, including DNA molecules, nucleosomes, transcription activities, chromatin loops, and chromatin organization by TADs and nuclear compartments, that potentially further influence cellular development into specific tissue types and relevant human diseases. The impact of DNA topology on chromatin regulation on different scales may also interact with each other.

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DNA topology interacts with chromatin factors and processes on a spectrum of scales from small to large, including DNA molecules, nucleosomes, transcription activities, chromatin loops, and chromatin organization by TADs and nuclear compartments, that potentially further influence cellular development into specific tissue types and relevant human diseases. The impact of DNA topology on chromatin regulation on different scales may also interact with each other.

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