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Doxorubicin Target & Off-Target Effects
Description
This template compares the on-target and off-target effects of doxorubicin, showing how the drug intercalates into DNA of cancer cells to trigger apoptosis and cause tumor regression. In cardiomyocytes, doxorubicin instead upregulates TNFR1, Fas, DR4, and DR5, driving apoptosis that leads to cardiac tissue damage.
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