Effects of Agomelatine on Agitation, Aggression, and Neuroprotection in Alzheimer's Disease

Agomelatine’s effects on agitation and aggression in Alzheimer’s may involve 5-HT₂C and melatonin receptors in key brain regions. Serotonergic pathways from the dorsal raphe project to these areas, most of which co-express melatonin receptors. Mechanistic insights are drawn from neuroanatomical studies of receptor distribution and brain regions linked to reactive aggression (Ng 2017; Whitestone 2019; Bertsch 2020; Vilaro 2020).

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