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BioRender Template
Endoplasmic reticulum stress and associated metabolic disorders
Creator
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Description
This figure shows how ER stress triggers the unfolded protein response (UPR) via PERK, IRE1 and ATF6 signalling pathways. Chronic activation of these pathways leads to insulin resistance, inflammation, lipid accumulation and apoptosis and contributes to metabolic disorders such as obesity, NAFLD and diabetes mellitus
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