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Epigenetic changes during aging

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Siem Beurskens

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Description: During aging DNA methylation increases at CpG islands but reduces in CpG-poor regions and endogenous retroviral (ERV) regions, resulting in less expression of housekeeping genes and the resurrection of ERVs. During aging the nuclear lamina erodes, making attached heterochromatin unstable. Also, a reduction in repressive histone markers and an increase in active histone markers and histone variant H3.3 cause increased chromatin accessibility and the expression of unwanted genes during aging.

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What does the Epigenetic changes during aging template show?

During aging DNA methylation increases at CpG islands but reduces in CpG-poor regions and endogenous retroviral (ERV) regions, resulting in less expression of housekeeping genes and the resurrection of ERVs. During aging the nuclear lamina erodes, making attached heterochromatin unstable. Also, a reduction in repressive histone markers and an increase in active histone markers and histone variant H3.3 cause increased chromatin accessibility and the expression of unwanted genes during aging.

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