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Epigenetic mechanisms at the interface of early-life adversities and mental health

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Bruno Berardino

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Description: Early-life adversities, such as malnutrition or maltreatment, affect development by activating the stress response and altering cortisol or neurotransmitter levels, which influence signal transduction. These signals modulate the epigenetic machinery (writers, readers, erasers), impacting DNA methylation and histone modifications, which affect gene expression and chromatin states. Non-coding RNAs and extracellular vesicles add complexity to the cellular responses.

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Early-life adversities, such as malnutrition or maltreatment, affect development by activating the stress response and altering cortisol or neurotransmitter levels, which influence signal transduction. These signals modulate the epigenetic machinery (writers, readers, erasers), impacting DNA methylation and histone modifications, which affect gene expression and chromatin states. Non-coding RNAs and extracellular vesicles add complexity to the cellular responses.

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