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BioRender Template
Epigenetic Regulation Via Histone Modification Regulates EMT
Creator
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Description
Epigenetic regulation through histone modification controls EMT. In epithelial-specific regulation, E-cadherin is acetylated and demethylated via KDM6A. During EMT, ZEB1, SNAI1/2, and SOX4 recruit HMTs and HDACs to repress E-cadherin transcription, promoting the mesenchymal phenotype. Adapted from Figure 5 of the article 'Spatial and Temporal Relationship between Epithelial–Mesenchymal Transition (EMT) and Stem Cells in Cancer'..
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