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ER stress associated NLRP3 inflammasome activation in hippocampus of Alzheimer disease
Creator
s
Description
Activation of ER is crucial. This study focuses on ER stress and the TXNIP/NLRP3 inflammasome in AD neuroinflammation. Increased inflammasome components, along with some proteins (p-Tau, B-amyloid) worsen neuroinflammation in AD patients. The unfolded protein response (UPR) in AD shows elevated BiP and phosphorylated eIF2a, inhibiting translation and inducing CHOP-mediated apoptosis. TXNIP activation by ER stress links neuroinflammation, suggesting protein regulation in the AD hippocampus.
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