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BioRender Template
Extrinsic and Intrinsic Pathways of Apoptosis Activation
Creator
s
Description
Intrinsic and extrinsic pathways of programmed cell death activate initiator caspases, which further activate executioner caspase-3. The extrinsic pathway requires signaling by death receptors, such as TNF, FASL, and TRAIL, while the intrinsic pathway depends on mitochondrial signals, including BID, BAX, and BAK. Both pathways converge to execute apoptosis efficiently.
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