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BioRender Template
Fibrotic Heart In Vitro Modelling
Creator
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Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
Myocardial infarction causes cardiomyocyte death and local remodeling of the extracellular matrix, leading to the progressive formation of a stiff fibrotic tissue mediated by profibrotic signals and mainly populated by cardiac fibroblasts. In vitro models of human pathological cardiac tissue that can reproduce the post-infarct microenvironment could greatly improve preclinical experimentation, helping in the selection of potential therapies for human heart regeneration.
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