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Flavonoids modulate apoptosis, cell cycle, DNA repair, and senescence pathways in cancer.
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Description
Flavonoids downregulate anti-apoptotic proteins (Bcl-2, Mcl-1, and Bcl-xL) and upregulate pro-apoptotic proteins (BAK, BAX, and BID). Flavonoids regulate cell cycle proteins (p21, CDK1, CDK2, CKD4, and cyclins: D1, A, B, and E). Flavonoids regulate DDR proteins (CHK1/2). Epi: Epigallocatechin; Cat: Catechin; Kae: Kaempferol; Myr: Myricetin; Que: Quercetin; Api: Apigenin; Gen: Genistein; Dai: Daidzein; Cya: Cyanidin; Vit: Vitexin; Lut: Luteolin; Nar: Naringenin; Tax: Taxifolin; Eri: Eriodictyol.
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