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Flavonoids modulate redox metabolism pathways in cancer.
Description
Flavonoids interact with NRF2, activating HO-1, NQO1, IDH1, ME1. Flavonoids inhibit HIF1A, reducing GLUT1 and glycolytic enzymes (PDK1, HK2, and PKM2), increasing the TCA cycle and not allowing the transformation of pyruvate into lactate. Flavonoids inhibit mTOR pathway. Que: Quercetin; Epi: Epigallocatechin, Kae: Kaempferol; Myr: Myricetin; Que: Quercetin; Api: Apigenin; Gen: Genistein; Dai: Daidzein; Lut: Luteolin; Nar: Naringenin; Tax: Taxifolin; Eri: Eriodictyol; Vit: Vitexin.
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