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BioRender Template
FLT3 Mutations in Acute Myeloid Leukemia (AML)
Description
This template compares wild type FLT3 receptor signaling, where ligand binding activates Ras/Raf to promote normal cell proliferation, with FLT3 mutations found in acute myeloid leukemia. The ITD and D835 mutations make the receptor constitutively active, driving Ras/Raf and Tyk2/STAT5 signaling that leads to increased cell proliferation.
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