BioRender Template

From CARs to CHARs and CAARs

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Sergi Betriu

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Description: Differences between a chimeric antigen receptor (CAR) and ligand-based CAR, such as CHARs or CAARs, lie in their recognition mechanism. While a CAR uses a single-chain variable fragment (ScFv) to recognize antigens, CHARs or CAARs have the antigen itself as an extracellular domain, which is recognized by a B cell receptor (BCR). CAARs or CHARs are emerging as targeted therapies for autoimmune diseases and the management of humoral rejection in kidney transplants.

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BioRender Template FAQs

What does the From CARs to CHARs and CAARs template show?

Differences between a chimeric antigen receptor (CAR) and ligand-based CAR, such as CHARs or CAARs, lie in their recognition mechanism. While a CAR uses a single-chain variable fragment (ScFv) to recognize antigens, CHARs or CAARs have the antigen itself as an extracellular domain, which is recognized by a B cell receptor (BCR). CAARs or CHARs are emerging as targeted therapies for autoimmune diseases and the management of humoral rejection in kidney transplants.

Is the From CARs to CHARs and CAARs template free to use?

Yes, you can customize this template with a free BioRender account (no credit card required). Paid plans unlock additional export formats, higher-resolution downloads, and publication permissions.

Can I edit or customize this template?

Yes, every element is fully editable. Icons, labels, colors, arrows, shapes and layout can all be changed to match your preferences or needs using BioRender's drag-and-drop editor. You can add or remove elements to fully customize your use case.

Is this template accepted for use in journals, theses, or grant applications?

Yes, BioRender icons and templates meet journal, grant, and copyright standards for publication, and many researchers cite BioRender directly in their figure legends.

How do I cite BioRender if I use this template?

Unlock publication permissions with a paid plan, and include 'Created with BioRender.com' in your figure legend, or cite BioRender directly per your journal's guidelines.

What is From CARs to CHARs and CAARs used for / who typically uses this template?

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