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BioRender Template
Functional Mechanisms of Antisense Oligonucleotides (ASOs)
Creator
s
Description
The figure illustrates some of the functional mechanisms through which ASOs binding to their mRNA target ultimately leads to a reduction in the target protein. The panel on the left illustrates an ASO binding to an mRNA target, activating the RNase H degradation pathway, leading to digestion of the mRNA-ASO heteroduplex. The panel on the right shows an ASO binding to its target mRNA and inhibiting the initiation or the continuation of protein translation through steric hindrance.
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