BioRender Template

G1/S Checkpoint

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BioRender Team

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Description:

This template shows regulation of the G1/S checkpoint, tracing how growth factors, TGF-beta, replicative senescence, oncogene stress, and DNA damage signal through p16, p21, p27, and p53 to control cyclin D/CDK4/6 and cyclin E/CDK2 complexes. Below, it shows how these complexes phosphorylate RB, releasing it from the E2F transcription factor to turn on S-phase genes.

Updated

August 2026

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