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Gaucher cell
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Description:
A Gaucher cell is a distinctive type of cell found in individuals with Gaucher disease, a lysosomal storage disorder. These cells are:
Enlarged macrophages (immune cells that normally digest cellular debris and pathogens),
Found primarily in the liver, spleen, and bone marrow,
Characterized by a crumpled tissue paper appearance of their cytoplasm under light microscopy, due to the accumulation of glucocerebroside, a lipid that the body is unable to break down.
Updated
August 2026
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A Gaucher cell is a distinctive type of cell found in individuals with Gaucher disease, a lysosomal storage disorder. These cells are:
Enlarged macrophages (immune cells that normally digest cellular debris and pathogens),
Found primarily in the liver, spleen, and bone marrow,
Characterized by a crumpled tissue paper appearance of their cytoplasm under light microscopy, due to the accumulation of glucocerebroside, a lipid that the body is unable to break down.