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BioRender Template
Genotype-Specific Synthetic Lethality
Description
This template shows genotype-specific synthetic lethality, comparing a normal cell with wild-type Gene A and Gene B to a cancer cell with a mutated Gene A, both subjected to Gene B inhibition. Inhibiting Gene B is tolerated in the normal cell because Gene A compensates, keeping the cell viable, but is lethal in the cancer cell because the mutated Gene A cannot take over Gene B's function.
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