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Glial Dystrophin associated Protein Complex

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Cloé Moëlo

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Description: In glial cells, the DAPC comprises on the cytosolic side the Dp71 isoform of dystrophin, α-dystrobrevin, and α1-syntrophin. Dystrophin anchors to the transmembrane dystroglycan complex (α and β1), and α1-syntrophin provides anchorage for aquaporins and ion channels to the membrane. Finally, on the extracellular side, the dystroglycan complex is linked to the α2-laminin/agrin complex, ensuring binding to the basal lamina.

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In glial cells, the DAPC comprises on the cytosolic side the Dp71 isoform of dystrophin, α-dystrobrevin, and α1-syntrophin. Dystrophin anchors to the transmembrane dystroglycan complex (α and β1), and α1-syntrophin provides anchorage for aquaporins and ion channels to the membrane. Finally, on the extracellular side, the dystroglycan complex is linked to the α2-laminin/agrin complex, ensuring binding to the basal lamina.

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