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BioRender Template
Glioblastoma Management Conundrums: Addressing the Immunotherapy Paradox
Creator
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Description
Glioblastoma , the most aggressive primary brain malignancy, faces persistent therapeutic limitations due to its infiltrative growth, tumor heterogeneity, and immunosuppressive microenvironment. While immunotherapeutic strategies—including checkpoint inhibitors, CAR-T cells, and oncolytic viruses—hold transformative potential, their clinical efficacy remains constrained by the blood-brain barrier's restrictive permeability, antigenic variability, and adaptive immune evasion mechanisms.
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