Graphic Abtract
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Description:
This graphic abstract outlines how the Salmonella spvC gene inhibits pyroptosis and intestinal inflammation to worsen systemic infection in mice, tracing several Salmonella strains through infection of C57BL/6 mice and J774A.1 cells. It shows spvC's phosphothreonine lyase activity suppressing pyroptosis and attenuating intestinal inflammation, which together promote bacterial dissemination throughout the mouse.
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This graphic abstract outlines how the Salmonella spvC gene inhibits pyroptosis and intestinal inflammation to worsen systemic infection in mice, tracing several Salmonella strains through infection of C57BL/6 mice and J774A.1 cells. It shows spvC's phosphothreonine lyase activity suppressing pyroptosis and attenuating intestinal inflammation, which together promote bacterial dissemination throughout the mouse.