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BioRender Template
HALLMARKS OF IMMUNOSENESCENCE
Creator
s
Description
Thymic involution reduces thymopoiesis and naive T cells, making the elderly more susceptible to diseases. Inflammaging, marked by chronic inflammation, impairs immune function. Senescent T cells shift to glycolysis, reducing proliferation and cytokine production. Hematopoietic stem cells (HSCs) undergo myeloid differentiation and reduced differentiation capabilities, altering immune cell composition. These changes collectively contribute to the decline in immune function with aging.
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