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BioRender Template
HER2 Signaling Pathway
Description
This template shows HER2 signaling initiated by different receptor dimer combinations, including EGFR homodimers, HER2/EGFR, HER2/HER3, HER2/HER4, and HER2 homodimers, each phosphorylated at the membrane. Signals converge on the RAS-RAF-MEK-ERK and PI3K-AKT pathways, which enter the nucleus to drive gene targets involved in survival, proliferation, and cell-cycle progression.
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