HIF1 signalling
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Description:
This template shows how HIF-1alpha is hydroxylated by prolyl hydroxylase under normoxia and targeted for degradation by VHL, while under hypoxia HIF-1alpha stabilizes and pairs with HIF-1beta to bind the hypoxia response element and drive transcription. Downstream target genes are grouped by function, including proliferation and apoptosis regulators, vascular tone genes, angiogenesis factors, erythropoiesis, and inflammation.
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This template shows how HIF-1alpha is hydroxylated by prolyl hydroxylase under normoxia and targeted for degradation by VHL, while under hypoxia HIF-1alpha stabilizes and pairs with HIF-1beta to bind the hypoxia response element and drive transcription. Downstream target genes are grouped by function, including proliferation and apoptosis regulators, vascular tone genes, angiogenesis factors, erythropoiesis, and inflammation.