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BioRender Template
Hippo Pathway in Mammals
Description
This template shows the Hippo signaling pathway in mammals, tracing the cascade from upstream receptors through FRMD6, Merlin, and KIBRA to the MST1/2-SAV1 and LATS1/2-MOB1 kinase complexes. Phosphorylated YAP/TAZ is bound by 14-3-3 and degraded, while unphosphorylated YAP/TAZ enters the nucleus to bind TEAD and activate genes involved in organ size, stem cell renewal, and cell survival.
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