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Histamine-mediated neuronal silencing schematics

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Siddharth R venkatesh

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Description: When no histamine is present, the HisCl channel remains closed and no influx of Cl ions is seen. Thus, the membrane potential of the is in the resting state. However, exposure to Histamine opens up the His-gated chloride channel. This influx of Cl ions hyperpolarises the neurons and inhibits/silences the generation of action potential and teh subsequent neuronal activity.

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What does the Histamine-mediated neuronal silencing schematics template show?

When no histamine is present, the HisCl channel remains closed and no influx of Cl ions is seen. Thus, the membrane potential of the is in the resting state. However, exposure to Histamine opens up the His-gated chloride channel. This influx of Cl ions hyperpolarises the neurons and inhibits/silences the generation of action potential and teh subsequent neuronal activity.

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