How Does the Lyme Vaccine Work? (Long)

This template explains how an mRNA-based Lyme disease vaccine works against Borrelia burgdorferi, the spiral-shaped bacteria transmitted by black-legged ticks, in five numbered steps from mRNA encoding 19 tick salivary proteins to antibody production and a rapid immune response at the bite site. A response timeline compares the vaccinated immune response, unvaccinated immune response, and window for Borrelia burgdorferi transmission over 72 hours after a tick bite.

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