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Inhibitory neurotransmission in the internal anal sphincter
Creator
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Description
Inhibitory neurotransmitters in the internal anal sphincter include nitric oxide (NO) and purines. When released from inhibitory neurons, NO targets Interstitial Cells of Cajal, whereas purines target PDGFRa+ cells. Cells in the IAS act as a coupled syncytium, therefore, changes in one cell type will dictate the activity of smooth muscle in the IAS leading to relaxation
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