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BioRender Template
Initiation of Germinal Center Response in Ectopic Lymphoid Structures
Description
This template shows how a germinal center response begins in ectopic lymphoid structures, starting with an antigen-presenting cell activating a T cell through MHC II/TCR interaction in the T cell-rich area. The activated T helper cell then migrates to the B cell-rich area, engaging a B cell through CD40/CD40L and ICOS/ICOSL signaling with IL-21, ultimately producing a mature B cell and follicular dendritic cell in the germinal center.
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