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Intoxication Process of Botulinum Neurotoxins
Creator
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Description
On the pre synaptic side of the peripheral synapse, the receptor binding domain first, binds to neuronal membrane by attaching to gangliosides and certain synaptic vesicle proteins.
The next phase involves receptor mediated endocytosis Causes the toxin to be internalised.
The toxins, light chain reaches the cytoplasm after crossing through the membrane of an endocytic vesicle.
The light chain, then cleaves polypeptides necessary for neurotransmitter release.
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