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Intracellular life cycle of B. pseudomallei: Mechanisms of host cell invasion, survival and spread
Creator
s
Description
• Adhesion to and invasion of host cell
o Pili, fimbriae, adhesion proteins BoaA, BoaB
• Phagosomal survival
o OxyR, KatG, AhpC; speG, dpsA
• Phagosomal escape
o T3SS
• Intracellular adaption and replication
o BLF1
• Cell-to-cell spread
o Host actin polymerisation
o BimA
o Fusion of host cell membranes to MNGCs
o T6SS
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