BioRender Template

IR induced Mito DNA release and cGAS activation

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Hailong Pei

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Description: This template shows how ionizing radiation triggers ATMLP O-GlcNAc glycosylation and mitochondrial DNA release through the BAK/BAX pore in epithelial cells, activating the cGAS-STING-IRF3 pathway. This leads to production of interferons, TNFs, ILs, and chemokines that recruit macrophages and ultimately drive fibrosis.

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BioRender Template FAQs

What does the IR induced Mito DNA release and cGAS activation template show?

This template shows how ionizing radiation triggers ATMLP O-GlcNAc glycosylation and mitochondrial DNA release through the BAK/BAX pore in epithelial cells, activating the cGAS-STING-IRF3 pathway. This leads to production of interferons, TNFs, ILs, and chemokines that recruit macrophages and ultimately drive fibrosis.

Is the IR induced Mito DNA release and cGAS activation template free to use?

Yes, you can customize this template with a free BioRender account (no credit card required). Paid plans unlock additional export formats, higher-resolution downloads, and publication permissions.

Can I edit or customize this template?

Yes, every element is fully editable. Icons, labels, colors, arrows, shapes and layout can all be changed to match your preferences or needs using BioRender's drag-and-drop editor. You can add or remove elements to fully customize your use case.

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What is IR induced Mito DNA release and cGAS activation used for / who typically uses this template?

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