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iron homeostasis
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Description:
The ferric iron (Fe3+) supplied by the diet reaches the duodenum. It is reduced to ferrous iron (Fe2+) by cytochrome B (Dcytb), a ferroreductase located at the apical pole of duodenal enterocytes. Fe2+ enters the cell via a divalent metal transporter (DMT1). Once in the cytoplasm, iron can be stored as ferritin (FTN), be used in cellular processes or enter the bloodstream via a transporter, ferroportin (FPN), located at the basolateral pole of enterocytes. etc.
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August 2026
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The ferric iron (Fe3+) supplied by the diet reaches the duodenum. It is reduced to ferrous iron (Fe2+) by cytochrome B (Dcytb), a ferroreductase located at the apical pole of duodenal enterocytes. Fe2+ enters the cell via a divalent metal transporter (DMT1). Once in the cytoplasm, iron can be stored as ferritin (FTN), be used in cellular processes or enter the bloodstream via a transporter, ferroportin (FPN), located at the basolateral pole of enterocytes. etc.