KRAS Signaling Pathways
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Description:
This template traces the KRAS signaling pathway starting from receptor tyrosine kinase activation, showing the GDP/GTP cycling of KRAS between inactive and active states regulated by GAP and GEF proteins. From active KRAS, the schematic branches into the PI3K-AKT-mTOR, RAF-MERK-ERK, and RAL-NF-kB arms that converge on the nucleus to drive proliferation, differentiation, and survival.
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This template traces the KRAS signaling pathway starting from receptor tyrosine kinase activation, showing the GDP/GTP cycling of KRAS between inactive and active states regulated by GAP and GEF proteins. From active KRAS, the schematic branches into the PI3K-AKT-mTOR, RAF-MERK-ERK, and RAL-NF-kB arms that converge on the nucleus to drive proliferation, differentiation, and survival.








