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L-PGDS association with β cell proliferation

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Md asrarul Islam

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Description: L-PGDS helps in the production of PGD2 which leads to PPARγ activation and adiponectin release. Adiponectin binds to Adipo R1/2, which stimulates ceramidase activity to produce sphingosine from ceramide. This sphingosine then converts to S1P and binds with S1P receptor. Downstream AMPK gets activated, which directly inhibits NFκB, leads to inhibition of β-cell apoptosis, and increases proliferation. Also, the binding of S1P to S1P-receptor increases the phosphorylation of AKT.

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L-PGDS helps in the production of PGD2 which leads to PPARγ activation and adiponectin release. Adiponectin binds to Adipo R1/2, which stimulates ceramidase activity to produce sphingosine from ceramide. This sphingosine then converts to S1P and binds with S1P receptor. Downstream AMPK gets activated, which directly inhibits NFκB, leads to inhibition of β-cell apoptosis, and increases proliferation. Also, the binding of S1P to S1P-receptor increases the phosphorylation of AKT.

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