BioRender Template

lactylation

Created by

Fan Yang

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Description:

This template shows how lactate is converted to lactyl-CoA by P300 and deposited as H3K18la marks near the METTL3 promoter, increasing METTL3 expression and m6A marking of PTEN mRNA, which YTHDF2 then degrades, reducing PTEN translation. An inset shows this pathway's effect on vascular wall thickening in a cross-section comparison.

Updated

July 2026

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