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BioRender Template
Macrophage derived foam cell formation
Creator
s
Description
Endothelial barrier damage allows LDL to enter intima and oxidizes into highly inflammatory oxLDL. Inflammatory response causes endothelial cells to produce chemokines, cytokines, and adhesion molecules, recruiting monocytes. Monocytes differentiate into macrophages due to cytokines such as M-CSF. Macrophages internalize oxLDL, forming foam cells. Foam cell formation is crucial in atherosclerosis, leading to programmed cell death and pro-inflammatory cytokine release.
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