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MALAT-1 biogenesis and mechanism of action
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Description
MALAT-1 is initially transcribed as a precursor immature transcript, which the enzyme RNAase P processes to produce mature MALAT-1. MALAT-1 decreases gene expression in many ways, including interfering with a transcription factor, interfering with RNA Pol II, therefore inhibiting transcription, interfering with mRNA splicing, interfering with epigenetic regulation leading to gene silencing and competing with miRNAs, and preventing mRNA transcriptions.
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