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MAPK Signaling Pathway
Description
This template shows the MAPK signaling pathway, tracing four parallel branches activated by G-protein coupled receptors, growth factors, stress or lipopolysaccharide, and inflammatory cytokines, each proceeding through MAP3K, MAP2K, and MAPK tiers (including ERK, JNK, and p38) across the cell and nuclear membranes. The pathway converges on transcription factors such as ELK1, AP1, STAT1, and c-Fos, driving cytokine production, apoptosis, migration, proliferation, and differentiation.
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