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Mast cell accumulation in the tissue drives vulvar sensitivity
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Description
Exposure to common environmental toxins or recurrent yeast infections lead to local mast cell and fibroblast activation, release of inflammatory cytokines and increased tactile sensitivity. Upon resolution of acute inflammation, sensitivity remains, with hyperinnervation, increased mast cell numbers, and infiltration of Tregs and resident memory T cells, and elevated inflammatory potential of fibroblasts. Treatment with imatinib, THC, or ketotifen, reduce mast cell accumulation and pain.
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