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BioRender Template
Mechanism of Action of Inclisiran for Hypercholesterolemia
Description
This template traces how inclisiran, a GalNAc-conjugated siRNA, enters hepatocytes via the asialoglycoprotein receptor and forms a RISC complex that degrades PCSK9 mRNA, reducing PCSK9 production and secretion. It shows how lower PCSK9 levels reduce LDL receptor degradation, enhancing LDL receptor recycling and LDL-C uptake into the cell.
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