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Mechanism of action of P. gingivalis virulence factors for rheumatoid arthritis
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Description
P. gingivalis invades by secreting gingipains, which shred and degrade different cell receptors and ECM components. This disrupts signaling pathways and promotes tissue damage. PPAD and human PAD then citrullinate the liberated peptides. These citrullinated peptide antigens are recognized by antigen-presenting cells, resulting in the generation of anti-citrullinated protein antibodies (ACPAs) by the B cells. These ACPAs are associated with an increased risk of RA.
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