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Mechanism of Action of Selective Serotonin Reuptake Inhibitors
Creator
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Description
As the name suggests, selective serotonin reuptake inhibitors (SSRIs) exert action by inhibiting the serotonin transporter at the presynaptic axon terminal. By inhibiting it, an increased amount of serotonin (5-hydroxytryptamine or 5-HT) remains in the synaptic cleft and can stimulate postsynaptic receptors for a more extended period.
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