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Mechanism of action of tramadol
Description
(1) Partial agonist of µ-opioid receptors in the central nervous system, inhibiting pain transmission; (2) inhibits the reuptake of serotonin and norepinephrine in the CNS, contributing to its central analgesic effect by potentiating pain-inhibiting pathways.
•Onset of action within 60 minutes; hepatic metabolism; renal excretion.
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